4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

Base Information

Chemical Name:4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide
CAS No.:74601-56-2
Molecular Formula:C₂₄H₂₀Cl₂N₂O₄
Molecular Weight:471.34
Hs Code.:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N<sup>α</sup>-(benzyloxycarbonyl)glycinanilide

Synonyms:4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

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Technology Process of 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

There total 5 articles about 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 5621-86-3
2',5-dichloro-2-methylaminobenzophenone

: 74601-56-2
4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; at -8 - -5 ℃;

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 74601-56-2
4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / SOCl₂, hexamethylphosphoramide / -8 - -5 °C

2: 1.) sodium hydride (50percent oil dispersion) / DMF, RT

With N,N,N,N,N,N-hexamethylphosphoric triamide; thionyl chloride; sodium hydride;

Reference yield:

: 29176-39-4
4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

: 74-88-4
methyl iodide

: 74601-56-2
4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF, oil, 2-5 deg C, 15 min, 2.) DMF, oil, 2-5 deg C, 2 h;
DOI:10.1021/jm00133a006