(S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate

Base Information

• Chemical Name: (S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate
• CAS No.: 1351987-23-9
• Molecular Formula: C₂₄H₂₇NO₅
• Molecular Weight: 409.482
• Mol file: 1351987-23-9.mol

Synonyms:(S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate

Chemical Property of (S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate

There total 1 articles about (S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

→ (S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate (1351987-23-9)

Guidance literature:

Reference yield: 95.0%

(S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate (1351987-23-9) → (S)-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl pentanoic acid (1351987-24-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 24h; under 760.051 Torr;

Reference yield:

(S)-benzyl-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl-pentanoate (1351987-23-9) → (S,E)-ethyl-3-acetoxy-5-(((S)-4-benzyloxazolidin-2-on-3-yl) carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoate (1351987-31-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 24 h / 760.05 Torr

2.1: magnesium chloride / tetrahydrofuran / 12 h / Reflux; Inert atmosphere

2.2: 3 h / 20 - 22 °C

2.3: pH 2

3.1: pyridine; titanium tetrachloride / dichloromethane; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 24 h / 760.05 Torr

5.1: triethylamine / dmap / 3 h / Inert atmosphere

With pyridine; hydrogen; titanium tetrachloride; triethylamine; magnesium chloride; dmap; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; 3.1: Knoevenagel Condensation;

Downstream raw materials:

(S)-3-((S)-4-benzyloxazolidin-2-on-3-yl)-carbonyl-4-methyl pentanoic acid

(S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-6-methyl-3-oxoheptanoate

(S)-ethyl 5-(((S)-4-benzyl-2-oxooxazolidin-3-yl)-carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)-benzyl)-3-methylbutylidene)-6-methyl-3-oxoheptanoate

(5S)-ethyl-5-(((S)-4-benzyloxazolidin-2-on-3-yl)carbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methyl-3-oxoheptanoate