1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

Base Information

Chemical Name:1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one
CAS No.:83704-97-6
Molecular Formula:C₁₉H₂₅F₃N₆O₇
Molecular Weight:506.439
Hs Code.:

1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-<N-(trifluoroacetyl)-N-(4-carbethoxycyclohexyl)amino>butan-2-one

Synonyms:1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

Suppliers and Price of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

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Chemical Property of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

Chemical Property:

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Technology Process of 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

There total 10 articles about 1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 83704-96-5
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4--2,2-(ethylenedioxy)butane

: 83704-97-6
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; at 55 - 60 ℃;
DOI:10.1021/jm00356a004

Reference yield:

: 6959-76-8
3-((4-(ethoxycarbonyl)phenyl)amino)propanoic acid

: 83704-97-6
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / H₂ / PtO₂ / acetic acid / 18 h / 2327.2 Torr

2: 90 percent / 18 h / Ambient temperature

3: thionyl chloride / benzene / 1 h / Heating

4: diethyl ether / 1 h / 25 °C

5: HBr / diethyl ether

6: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

7: p-toluenesulfonic acid / benzene / 6 h / Heating

8: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

9: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

10: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; sodium azide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; diethyl ether; water; acetic acid; benzene;
DOI:10.1021/jm00356a004

Reference yield:

: 83704-89-6
N-(4-carbethoxycyclohexyl)-β-alanine

: 83704-97-6
1-<(2-amino-4-hydroxy-5-nitropyrimidin-6-yl)amino>-4-butan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / 18 h / Ambient temperature

2: thionyl chloride / benzene / 1 h / Heating

3: diethyl ether / 1 h / 25 °C

4: HBr / diethyl ether

5: 91 percent / sodium azide / methanol; H₂O / 3.5 h / Ambient temperature

6: p-toluenesulfonic acid / benzene / 6 h / Heating

7: H₂ / 10percent Pd/C / 18 h / 517.1 Torr

8: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, reflux, 3 h

9: 94 percent / trifluoroacetic acid, 0.1 N HCl / 55 - 60 °C

With 4-methyl-morpholine; hydrogenchloride; thionyl chloride; sodium azide; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; water; benzene;
DOI:10.1021/jm00356a004