3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

Base Information

Chemical Name:3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide
CAS No.:1346567-72-3
Molecular Formula:C₂₄H₂₀ClN₃O₂
Molecular Weight:417.895
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

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Chemical Property of 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

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Technology Process of 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

There total 8 articles about 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346569-76-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

: 593-51-1
methylamine hydrochloride

: 1346567-72-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 22 - 26 ℃; for 16h;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1346567-72-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 3 h / Reflux

1.2: 0.5 h / Reflux

2.1: sulfuric acid / 16 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

4.1: sodium hydroxide; water / ethanol / 16 h / 22 - 26 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 22 - 26 °C

With sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Perkin Reaction;

Reference yield:

: 57892-76-9
2-chloromethylimidazo[1,2-a]pyridine

: 1346567-72-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]-N-methyl-prop-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2: sodium hydroxide; water / ethanol / 16 h / 22 - 26 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 16 h / 22 - 26 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;