3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

Base Information

Chemical Name:3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid
CAS No.:1346569-76-3
Molecular Formula:C₂₃H₁₇ClN₂O₃
Molecular Weight:404.853
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

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Chemical Property of 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

There total 7 articles about 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346569-79-6
ethyl 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoate

: 1346569-76-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

Guidance literature:: ethyl 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoate; With water; sodium hydroxide; In ethanol; at 22 - 26 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1346569-76-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / 3 h / Reflux

1.2: 0.5 h / Reflux

2.1: sulfuric acid / 16 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

4.1: sodium hydroxide; water / ethanol / 16 h / 22 - 26 °C

With sulfuric acid; water; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; 1.1: Perkin Reaction;

Reference yield:

: 57892-76-9
2-chloromethylimidazo[1,2-a]pyridine

: 1346569-76-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2: sodium hydroxide; water / ethanol / 16 h / 22 - 26 °C

With water; potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;