Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
CAS No.:205748-20-5
Molecular Formula:C₁₄H₁₄Br₂O₄
Molecular Weight:406.071
Hs Code.:

Synonyms:Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

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Technology Process of Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

There total 1 articles about Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75288-20-9
2-bromo-2-(4-bromophenyl)acetyl chloride

: 599-04-2
(R)-Pantolacton

: 205748-20-5
Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jo9712714

Reference yield: 76.0%

: 205748-20-5
Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

: 103-49-1
dibenzylamine

: 205748-26-1
(S)-(4-Bromo-phenyl)-dibenzylamino-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo9712714

Reference yield:

: 205748-20-5
Bromo-(4-bromo-phenyl)-acetic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

: 611-24-5
o-(N-methylamino)phenol

: (S)-3-(p-bromophenyl)-4-methyl-2-oxo-3,4-dihydro-2H-1,4-benzoxazine

: (R)-3-(p-bromophenyl)-4-methyl-2-oxo-3,4-dihydro-2H-1,4-benzoxazine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Overall yield = 47 %; stereoselective reaction; Inert atmosphere;
DOI:10.1080/00397911.2018.1444769