2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide

Base Information

• Chemical Name: 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide
• CAS No.: 1380068-74-5
• Molecular Formula: C₁₄H₁₈BrNO₃
• Molecular Weight: 328.206
• Mol file: 1380068-74-5.mol

Synonyms:2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide

Chemical Property of 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide

There total 3 articles about 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-bromo-4-(cyclopropylmethoxy)phenyl]acetic acid (1380068-73-4) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide (1380068-74-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetonitrile; at 20 ℃; for 15h;

Reference yield:

cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate (1380068-72-3) → 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide (1380068-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 2 h / 50 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; acetonitrile;

Reference yield:

2-(2-bromo-4-hydroxyphenyl)acetic acid (88491-44-5) → 2-[2-bromo-4-(cyclopropylmethoxy)phenyl]-N-methoxy-N-methylacetamide (1380068-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

2: sodium hydroxide; water / methanol / 2 h / 50 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

[2-bromo-4-(cyclopropylmethoxy)phenyl]acetic acid

N,O-dimethylhydroxylamine*hydrochloride

2-(2-bromo-4-hydroxyphenyl)acetic acid

cyclopropylmethyl [2-bromo-4-(cyclopropylmethoxy)phenyl]acetate

Downstream raw materials:

1-[2-bromo-4-(cyclopropylmethoxy)phenyl]propan-2-one