(4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

Base Information

Chemical Name:(4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one
CAS No.:1356003-67-2
Molecular Formula:C₂₆H₂₂N₂O₅
Molecular Weight:442.471
Hs Code.:

Synonyms:(4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

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Chemical Property of (4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

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Technology Process of (4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

There total 4 articles about (4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1356003-62-7
(5Z)-3-benzyloxycarbonyl-2-(benzylsulfanyl)-5-(4-methoxybenzylidene)-4,5-dihydro-1H-imidazol-4-one

: 5720-07-0
4-methoxyphenylboronic acid

: 1356003-67-2
(4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; at 70 ℃; for 24h; Inert atmosphere;
DOI:10.1055/s-0030-1260259

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1356003-67-2
(4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; acetic acid / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / tetrahydrofuran / 24 h / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; sodium acetate; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; 3: Liebeskind-Srogl coupling reaction;
DOI:10.1055/s-0030-1260259

Reference yield:

: 95474-45-6,1809028-84-9
5-p-methoxybenzylidene-2-thiohydantoin

: 1356003-67-2
(4Z)-1-benzyloxycarbonyl-4-(4-methoxybenzylidene)-2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazol-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / tetrahydrofuran / 24 h / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; 3: Liebeskind-Srogl coupling reaction;
DOI:10.1055/s-0030-1260259