Aziridine

Base Information

• Chemical Name: Aziridine
• CAS No.: 9002-98-6
• Deprecated CAS: 99932-76-0
• Molecular Formula: (C2H5N)x
• Molecular Weight: 43.06780
• Hs Code.: 39019090
• European Community (EC) Number: 205-793-9,618-346-1,680-333-1,686-272-7
• ICSC Number: 0100
• NSC Number: 196335,134422,124036,124035,124034
• UN Number: 1185
• UNII: 54P5FEX9FH
• DSSTox Substance ID: DTXSID8020599
• Nikkaji Number: J2.966A
• Wikipedia: Aziridine
• Wikidata: Q409141
• NCI Thesaurus Code: C1009
• Metabolomics Workbench ID: 52044
• ChEMBL ID: CHEMBL540990

Synonyms:aziridine;aziridine, conjugate acid;ethyleneimine;ethylenimine

Chemical Property of Aziridine

Chemical Property:

• Vapor Pressure: 9 mmHg ( 20 °C)
• Melting Point: 59-60°C
• Refractive Index: n20/D 1.5290
• Boiling Point: 250 °C(lit.)
• Flash Point: >230 °F
• PSA: 21.94000
• Density: 1.030 g/mL at 25 °C
• LogP: -0.08160
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 43.042199164
• Heavy Atom Count: 3
• Complexity: 10.3
• Transport DOT Label: Poison Inhalation Hazard Flammable Liquid

Purity/Quality:

99%min ^*data from raw suppliers

Polyethyleneimine (ca. 30% in Water) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:Harmful if swallowed.
• Hazard Codes: Xn,N,Xi
• Statements: 22-43-51/53-36/38
• Safety Statements: 22-24/25-61-36/37-37-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: UVCB,Toxic Gases & Vapors -> Other Toxic Gases & Vapors
• Canonical SMILES: C1CN1
• Inhalation Risk: A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. The substance may cause effects on the central nervous system, kidneys and liver. Exposure far above the OEL could cause death. The effects may be delayed.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans. May cause heritable genetic damage to human germ cells.
• Description: Polyethyleneimine (PEI), an organic polyamine polymer, is one of the most prominent examples of cationic polymers capable of gene transfection in vitro and in vivo into various cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry.
• Uses: Polyethyleneimine is used as a polyelectrolyte multilayer on charged surfaces to provide a biocompatible coating on surfaces.1Detergents, adhesives, water treatment, printing inks, dyes, cosmetics, and paper industry, adhesion promoter, lamination primer, fixative agent, flocculant, cationic dispersant, stability enhancer, surface activator, chelating agent, scavenger for aldehydes and oxides. Polyethyleneimine acts as a protein precipitant used to purify proteins. It is used as a chelating agent and as a scavenger for aldehydes and oxides. It is also used in detergents, paper industry, dyes, printing inks and in water treatment. Branched polyethyleneimine (PEI) is widely used in many applications due to its polycationic character. Unlike its linear equivalent, branched PEI contains primary, secondary, and tertiary amines. Primarily utilized in industrial applications, high molecular weight PEI has been used as a flocculating agent, textile coating, adhesion promoter, enzyme carrier, and as a material for CO2 capture.

Technology Process of Aziridine

There total 52 articles about Aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(phenylaminocarbonyl)aziridine (13279-22-6) + dimethyl amine (124-40-3) → ethyleneimine (151-56-4,9002-98-6) + fenuron (101-42-8)

Guidance literature:

In ethanol; at 18 - 25 ℃; for 168h;

Reference yield: 90.0%

methyl aziridine-1-carboxylate (671-50-1) → ethyleneimine (151-56-4,9002-98-6) + methyl carbamate (598-55-0)

Guidance literature:

With ammonia; In ethanol; at 18 - 25 ℃; for 24h;

Reference yield: 88.0%

1-(phenylaminocarbonyl)aziridine (13279-22-6) → ethyleneimine (151-56-4,9002-98-6) + phenyl carbamate (64-10-8)

Guidance literature:

With ammonia; In ethanol; at 18 - 25 ℃; for 168h;

upstream raw materials:

tetrachloromethane

sulfuric acid mono-(2-amino-ethyl ester)

2-bromoethylamine hydrobromide

2-bromoethylamine

Downstream raw materials:

tetramin

1-Ethylenimino-2-methyl-buten-(3)-ol-(2)

bis-aziridin-1-yl-phenyl-phosphine oxide

aziridin-1-yl-phenyl-phosphinic acid ethyl ester

Refernces

Low molecular weight PEI-based biodegradable lipopolymers as gene delivery vectors

10.1039/c2ob27211c

This research investigates the development and optimization of low molecular weight (LMW) polyethyleneimine (PEI)-based biodegradable lipopolymers (LPs) as non-viral gene delivery vectors. The study aims to enhance gene transfection efficiency while maintaining low cytotoxicity, addressing limitations of both viral vectors and high molecular weight PEI. Polyethyleneimine (PEI) serves as a foundational component for the development of gene delivery vectors. PEI is a cationic polymer known for its ability to condense nucleic acids through electrostatic interactions, forming complexes that protect DNA from degradation and facilitate its cellular uptake. The research concluded that the structure of the hydrophobic chain significantly impacts transfection efficiency, with shorter chains like decoyl in LP2 yielding the best results. The study also highlighted the importance of balancing molecular weight, charge density, and hydrophobicity to optimize the performance of these lipopolymers as gene delivery agents.

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