(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester
CAS No.:918437-79-3
Molecular Formula:C₂₁H₃₂N₂O₄
Molecular Weight:376.496
Hs Code.:

(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

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Chemical Property of (1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

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Technology Process of (1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

There total 7 articles about (1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055423-27-2
(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]hexahydro-2-oxo-1H-azepine-1-carboxylic acid phenylmethyl ester

: 918437-79-3
(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 g / H₂ / Pd-C / ethyl acetate / 8 h

2: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

3: HCl / ethyl acetate / 1.5 h / 20 °C

4: K₂CO₃; NaI / dimethylformamide / 2 h / 70 °C

5: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

With hydrogenchloride; hydrogen; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0670761

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 918437-79-3
(1-benzyl-2-oxo-azepan-3-yl)-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 12.7 g / N-hydrosuccinimide; DCC / ethyl acetate / 5 h / 20 °C

2: 74 g / H₂ / Pd-C / ethyl acetate / 8 h

3: 75 percent / potassium hexamethyldisilazide / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

4: HCl / ethyl acetate / 1.5 h / 20 °C

5: K₂CO₃; NaI / dimethylformamide / 2 h / 70 °C

6: 748 mg / diisopropylethylamine / CH₂Cl₂ / 11 h / 20 °C

With Succinimide; hydrogenchloride; hydrogen; potassium hexamethylsilazane; potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja0670761