(2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

Base Information

Chemical Name:(2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine
CAS No.:132430-68-3
Molecular Formula:C₃₄H₃₅NO₃
Molecular Weight:505.657
Hs Code.:

Synonyms:(2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

Suppliers and Price of (2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

Chemical Property:

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Technology Process of (2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

There total 6 articles about (2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 100-39-0
benzyl bromide

: 113571-58-7
(2R,3S,4R)-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

: 132430-68-3
(2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

Guidance literature:: With potassium carbonate; In acetone; for 1h; Ambient temperature;
DOI:10.1248/cpb.38.2712

Reference yield:

: 101758-68-3
(R)-(+)-5-triphenylmethyloxymethyl-2 (5H)-furanone

: 132430-68-3
(2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / OsO₄, N-methylmorpholine N-oxide / H₂O; acetone

2: p-TsOH / acetone

3: 1.) LiAlH₄; 2.) pyridine; 3.) NaN₃ / 1.) THF; 3.) DMF, 130 deg C

4: 65 percent / H₂ / Pd black / ethanol

5: K₂CO₃ / ethanol

With pyridine; lithium aluminium tetrahydride; sodium azide; hydrogen; potassium carbonate; toluene-4-sulfonic acid; osmium(VIII) oxide; palladium; 4-methylmorpholine N-oxide; In ethanol; water; acetone;
DOI:10.1248/cpb.35.2140

Reference yield:

: 113571-56-5
(2S,3S,4S)-2,3-isopropylidenedioxy-4-trityloxymethyl-4-butanolide

: 132430-68-3
(2R,3S,4R)-N-benzyl-3,4-(isopropylidenedioxy)-2-(trityloxymethyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiAlH₄; 2.) pyridine; 3.) NaN₃ / 1.) THF; 3.) DMF, 130 deg C

2: 65 percent / H₂ / Pd black / ethanol

3: K₂CO₃ / ethanol

With pyridine; lithium aluminium tetrahydride; sodium azide; hydrogen; potassium carbonate; palladium; In ethanol;
DOI:10.1248/cpb.35.2140