(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Base Information

Chemical Name:(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester
CAS No.:869964-23-8
Molecular Formula:C₃₂H₆₀O₆Si₃
Molecular Weight:625.081
Hs Code.:

Synonyms:(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Suppliers and Price of (2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

There total 5 articles about (2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 869964-35-2
(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methylpent-4-enyl)-3-methylbenzoic acid methyl ester

: 869964-23-8
(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Guidance literature:: (2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methylpent-4-enyl)-3-methylbenzoic acid methyl ester; With ozone; In dichloromethane; at -78 ℃;

With triphenylphosphine;
DOI:10.1021/ja207331m

Reference yield:

: 869964-21-6
4,6-bis-tert-butyldimethylsilanyloxy-3-methyl-2-(2-oxoethyl)benzoic acid methyl ester

: 869964-23-8
(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether; tetrahydrofuran; hexane / 2.5 h / -78 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

3.1: ozone / CH₂Cl₂ / -78 °C

3.2: triphenylphosphine / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; ozone; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1.1: Brown crotylation;
DOI:10.1021/ol0520267

Reference yield:

: 869964-34-1
4,6-bis-tert-butyldimethylsilanyloxy-2-methoxycarbonylmethyl-3-methylbenzoic acid methyl ester

: 869964-23-8
(2R,3R)-4,6-bis-tert-butyldimethylsilanyloxy-2-(2-tert-butyldimethylsilanyloxy-3-methyl-4-oxobutyl)-3-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-iso-butylaluminum hydride / CH₂Cl₂; hexane / 2 h / -78 °C

2.1: diethyl ether; tetrahydrofuran; hexane / 2.5 h / -78 °C

3.1: 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

4.1: ozone / CH₂Cl₂ / -78 °C

4.2: triphenylphosphine / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; diisobutylaluminum hydride; ozone; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 2.1: Brown crotylation;
DOI:10.1021/ol0520267