ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Base Information

Chemical Name:ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate
CAS No.:1187857-72-2
Molecular Formula:C₂₅H₃₀FNO₅
Molecular Weight:443.515
Hs Code.:

Synonyms:ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

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Chemical Property of ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

There total 9 articles about ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623-73-4
diazoacetic acid ethyl ester

: 1187857-71-1
((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl-3-fluorophenyl(phenyl)carbamate

: 1187857-72-2
ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: With dirhodium tetraacetate; In dichloromethane; at 10 - 30 ℃; Large scale;
DOI:10.1021/acs.jmedchem.6b00871

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1187857-72-2
ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate / toluene / 3 h / 105 °C / Large scale

2: pyridine / dichloromethane / 0 - 25 °C / Inert atmosphere; Large scale

3: acetonitrile / 20 - 25 °C / Large scale

4: pyridine / acetonitrile / 18 h / 53 °C / Large scale

5: dirhodium tetraacetate / dichloromethane / 10 - 30 °C / Large scale

With pyridine; dirhodium tetraacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00871

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1187857-72-2
ethyl 2-(((1R,4r)-4-(((3-fluorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate / toluene / 3 h / 105 °C / Large scale

2: pyridine / dichloromethane / 0 - 25 °C / Inert atmosphere; Large scale

3: acetonitrile / 20 - 25 °C / Large scale

4: pyridine / acetonitrile / 18 h / 53 °C / Large scale

5: dirhodium tetraacetate / dichloromethane / 10 - 30 °C / Large scale

With pyridine; dirhodium tetraacetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium t-butanolate; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.6b00871