methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Base Information

• Chemical Name: methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
• CAS No.: 1361050-75-0
• Molecular Formula: C₁₉H₁₈F₃NO₄
• Molecular Weight: 381.351
• Mol file: 1361050-75-0.mol

Synonyms:methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Chemical Property of methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

There total 6 articles about methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid (1246960-25-7) → methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate (1361050-75-0)

Guidance literature:

With ammonium cerium (IV) nitrate; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2020.115861

Reference yield: 96.0%

methyl 3-(((R)-1-phenylethyl)amino)-4-(2,3,5-trifluorophenyl)butanoate + benzyl chloroformate (501-53-1,94274-21-2) → methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate (1361050-75-0)

Guidance literature:

methyl 3-(((R)-1-phenylethyl)amino)-4-(2,3,5-trifluorophenyl)butanoate; With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 24h;

benzyl chloroformate; With triethylamine; In dichloromethane; at 25 ℃; for 5h; Cooling with ice;

Reference yield: 79.0%

(R)-4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid (1361050-70-5) + benzyl alcohol (100-51-6,185532-71-2) → methyl (R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate (1361050-75-0)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 2h;

upstream raw materials:

(R)-4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid

benzyl alcohol

(E)-1-benzyl-4-methyl-2-(2,4,5-trifluorobenzylidene)succinate

benzyl chloroformate

Downstream raw materials:

(R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid