3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

Base Information

Chemical Name:3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one
CAS No.:260366-85-6
Molecular Formula:C₂₅H₃₂N₂O₂
Molecular Weight:392.541
Hs Code.:

Synonyms:3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

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Chemical Property of 3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

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Technology Process of 3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

There total 8 articles about 3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 260366-84-5
3-benzylamino-1-[2-(4-methoxyphenyl)ethyl]-1-azaspiro[4.5]decan-8-one ethylene acetal

: 260366-85-6
3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 260366-85-6
3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

Guidance literature:: Multi-step reaction with 7 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

5: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

6: 0.59 g / NaBH₄ / methanol / 0 - 20 °C

7: 79 percent / aq. HCl / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation / 5: Condensation / 6: Reduction / 7: Hydrolysis;
DOI:10.1016/S0968-0896(99)00250-3

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 260366-85-6
3-benzylamino-1-[2-(4-methoxy-phenyl)-ethyl]-1-aza-spiro[4.5]decan-8-one

Guidance literature:: Multi-step reaction with 7 steps

1: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

2: 12 g / CH₂Cl₂; diethyl ether / 4 h / 20 °C

3: 51 percent / aq. NaHCO₃; I₂ / CH₂Cl₂ / 12 h / 20 °C

4: 80 percent / AgBF₄; DMSO / 12 h / 20 °C

5: molecular sieves / CH₂Cl₂ / 4 h / 20 °C

6: 0.59 g / NaBH₄ / methanol / 0 - 20 °C

7: 79 percent / aq. HCl / tetrahydrofuran / 12 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; silver tetrafluoroborate; molecular sieve; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Condensation / 2: Grignard reaction / 3: Cyclization / 4: Oxidation / 5: Condensation / 6: Reduction / 7: Hydrolysis;
DOI:10.1016/S0968-0896(99)00250-3