ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

Base Information

Chemical Name:ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate
CAS No.:1092728-42-1
Molecular Formula:C₁₇H₂₁F₂NO₄
Molecular Weight:341.355
Hs Code.:

Synonyms:ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

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Chemical Property of ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

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Technology Process of ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

There total 6 articles about ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092728-41-0
ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5-oxocyclohexanecarboxylate

: 1092728-42-1
ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

Guidance literature:: ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5-oxocyclohexanecarboxylate; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In toluene; at 20 ℃; Cooling with ice;

With sodium periodate; ruthenium trichloride; In water; acetonitrile; at 20 ℃; Cooling with ice;

Reference yield:

: 121210-56-8
ethyl 8-hydroxy-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1092728-42-1
ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 17 h / 70 °C / Reflux

2.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

2.2: 2 h / 0 - 10 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

4.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

5.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice

6.2: 20 °C / Cooling with ice

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium carbonate; toluene-4-sulfonic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; acetone; toluene; isobutyric Acid;

Reference yield:

: 1092728-38-5
ethyl (7S,8R)-8-{[(1R)-1-phenylethyl]amino}-1,4-dioxaspiro[4.5]decane-7-Carboxylate hydrobromide

: 1092728-42-1
ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

2.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

3.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice

4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice

4.2: 20 °C / Cooling with ice

With hydrogenchloride; hydrogen; sodium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; acetone; toluene;