(E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester

Base Information

• Chemical Name: (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester
• CAS No.: 115666-14-3
• Molecular Formula: C₁₃H₁₃F₃O₄S
• Molecular Weight: 322.305
• Mol file: 115666-14-3.mol

Synonyms:(E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester

Chemical Property of (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester

There total 1 articles about (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + ethyl methanesulfonylacetate (4455-15-6) → (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester (115666-14-3)

Guidance literature:

With piperidine; acetic acid; In toluene; Heating;

DOI:10.1016/j.tet.2007.04.091

Reference yield: 72.0%

vinylmagnesium chloride (3536-96-7) + (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester (115666-14-3) → ethyl 2-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)pent-4-enoate (631898-72-1)

Guidance literature:

vinylmagnesium chloride; With copper(l) iodide; In tetrahydrofuran; at -78 - -40 ℃; for 0.166667h;

(E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 1h; Further stages.;

DOI:10.1016/j.tet.2007.04.091

Reference yield:

vinyl magnesium bromide (1826-67-1) + (E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester (115666-14-3) → ethyl 2-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)pent-4-enoate (631898-72-1)

Guidance literature:

vinyl magnesium bromide; With copper(l) iodide; In tetrahydrofuran; at -78 ℃;

(E)-2-Methanesulfonyl-3-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester; In tetrahydrofuran; at -78 ℃;

DOI:10.1055/s-2003-41011

upstream raw materials:

4-Trifluoromethylbenzaldehyde

ethyl methanesulfonylacetate

Downstream raw materials:

ethyl 2-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)pent-4-enoate

(E)-7-(4-methoxyphenyl)-7-oxo-4-(3-trifluoromethylphenyl)hept-2-enoic acid ethyl ester