benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

Base Information

Chemical Name:benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate
CAS No.:1059147-41-9
Molecular Formula:C₃₁H₃₀N₄O₅S
Molecular Weight:570.669
Hs Code.:

Synonyms:benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

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Chemical Property of benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

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Technology Process of benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

There total 6 articles about benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059147-38-4
benzyl 2-(4-((pyridin-2-ylmethylamino)methyl)benzoyl)-pyrazolidine-1-carboxylate

: 98-09-9
benzenesulfonyl chloride

: 1059147-41-9
benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 57699-90-8
benzyl pyrazolidine-1-carboxylate hydrochloride

: 1059147-41-9
benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.1: methanol / 1.5 h / 50 °C

3.2: 1 h / 0 °C

4.1: triethylamine / tetrahydrofuran / 4 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 57699-88-4
1-tert-butoxycarbonyl-2-carbobenzyloxyhydrazine

: 1059147-41-9
benzyl 2-(4-((N-(pyridin-2-ylmethyl)phenylsulfonamido)-methyl)benzoyl)pyrazolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 17 h / 20 °C

2.1: thionyl chloride / methanol / 16 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 18 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

5.1: methanol / 1.5 h / 50 °C

5.2: 1 h / 0 °C

6.1: triethylamine / tetrahydrofuran / 4 h / 20 °C

With thionyl chloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;