6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

Base Information

• Chemical Name: 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide
• CAS No.: 132735-19-4
• Molecular Formula: C₁₇H₁₇ClN₂S*HI
• Molecular Weight: 444.767
• Mol file: 132735-19-4.mol

Synonyms:6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

Chemical Property of 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

There total 3 articles about 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl iodide (75-03-6) + 6-Chloro-1-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydroquinazoline (26920-08-1) → 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide (132735-19-4) + 6-chloro-1-methyl-4-phenyl-3,4-dihydro-1H-quinazolin-2-one (26772-95-2)

Guidance literature:

for 3h; Heating;

Reference yield:

5-chloro-2-(methylamino)benzophenone (1022-13-5) → 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide (132735-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Na-Hg / ethanol / 9 h / 80 °C

2: 80 percent / aq. HCl / 1.5 h / 80 °C

3: 90 percent / 3 h / Heating

With sodium amalgam; In hydrogenchloride; ethanol;

Reference yield:

2-methylamino-5-chlorobenzhydrol (13386-35-1) → 6-Chloro-2-ethylthio-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide (132735-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / aq. HCl / 1.5 h / 80 °C

2: 90 percent / 3 h / Heating

In hydrogenchloride;

upstream raw materials:

ethyl iodide

6-Chloro-1-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydroquinazoline

2-methylamino-5-chlorobenzhydrol

5-chloro-2-(methylamino)benzophenone

Downstream raw materials:

6-Chloro-1-methyl-2-<2-(4-nitrobenzylidene)-hydrazino>-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

6-Chloro-1-methyl-2-<2-(2-nitrobenzylidene)-hydrazino>-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

2-(2-Benzylidenehydrazino)-6-chloro-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide

6-Chloro-2-(2-ethylidenehydrazino)-1-methyl-4-phenyl-1H-1,4-dihydroquinazoline hydroiodide