(1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate

Base Information

• Chemical Name: (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate
• CAS No.: 221675-92-9
• Molecular Formula: C₂₁H₂₈NO₇PS
• Molecular Weight: 469.496
• Mol file: 221675-92-9.mol

Synonyms:(1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate

Chemical Property of (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate

There total 4 articles about (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2,2'-dipyridyl disulfide bis-N-oxide (3696-28-4) + 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamic acid (221675-88-3) → (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate (221675-92-9)

Guidance literature:

With tributylphosphine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(98)01143-0

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate (221675-92-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) LDA / 1) THF, -78 deg C, 20 min, 2) THF

3: 70 percent / CAN / acetonitrile; H₂O / 1 h / Ambient temperature

4: 65 percent / PBu₃ / CH₂Cl₂ / 2 h / Ambient temperature

With ammonium cerium(IV) nitrate; tributylphosphine; lithium diisopropyl amide; In dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(98)01143-0

Reference yield:

3-hydroxy-3-(4-methoxy-phenyl)-2,2-dimethyl-propionic acid 2,4-dimethoxy-benzyl ester → (1H)-2-thioxo-1-pyridyl 3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamate (221675-92-9)

Guidance literature:

Multi-step reaction with 3 steps

2: 70 percent / CAN / acetonitrile; H₂O / 1 h / Ambient temperature

3: 65 percent / PBu₃ / CH₂Cl₂ / 2 h / Ambient temperature

With ammonium cerium(IV) nitrate; tributylphosphine; In dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(98)01143-0

upstream raw materials:

2,2'-dipyridyl disulfide bis-N-oxide

3-(diethylphosphatoxy)-2,2-dimethyldihydro-p-methoxycinnamic acid

4-methoxy-benzaldehyde

2,4-dimethoxybenzyl 2,2-dimethyl-3-(diethylphosphatoxy)dihydro-p-methoxycinnamate

Downstream raw materials:

carbon dioxide

pyridine-2-ylsulfanyl radical

2-(diethoxyphosphatoxy)-2-(p-methoxyphenyl)-1,1-dimethylethyl radical