Plafibride

Base Information

• Chemical Name: Plafibride
• CAS No.: 63394-05-8
• Molecular Formula: C16H22 Cl N3 O4
• Molecular Weight: 355.821
• Hs Code.: 2934999090
• European Community (EC) Number: 264-121-2
• UNII: 5J7C4JZ564
• DSSTox Substance ID: DTXSID1023491
• Nikkaji Number: J19.586C
• Wikidata: Q27262403
• NCI Thesaurus Code: C66444
• ChEMBL ID: CHEMBL2107129
• Mol file: 63394-05-8.mol

Synonyms:2-CIMMU;ITA 104;N-(2-(4-chlorophenoxy)isobutyryl)-N-morpholinomethylurea;plafibride

Chemical Property of Plafibride

Chemical Property:

• Melting Point: 100-102°
• Refractive Index: 1.6800 (estimate)
• PSA: 79.90000
• Density: 1.251g/cm³
• LogP: 2.33260
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 355.1298839
• Heavy Atom Count: 24
• Complexity: 433

Purity/Quality:

99% ^*data from raw suppliers

PLAFIBRIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)NC(=O)NCN1CCOCC1)OC2=CC=C(C=C2)Cl

Technology Process of Plafibride

There total 3 articles about Plafibride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(p-chlorophenoxy)-isobutyrylurea (29973-16-8) → Perifunal (63394-05-8)

Guidance literature:

In 1,4-dioxane; water; for 4h; Heating;

Reference yield:

clofibryl chloride (5542-60-9) → Perifunal (63394-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.6 percent / petroleum ether; pyridine / 3 h / Heating

2: 86 percent / dioxane; H₂O / 4 h / Heating

In 1,4-dioxane; pyridine; water; Petroleum ether;

Reference yield:

→ Perifunal (63394-05-8)

Guidance literature:

Morpholin, HCHO, entspr. Harnstoff;

upstream raw materials:

morpholine

formaldehyd

2-(p-chlorophenoxy)-isobutyrylurea

clofibryl chloride

Downstream raw materials:

2-(p-chlorophenoxy)-isobutyrylurea

Clofibric acid

Refernces