4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

Base Information

Chemical Name:4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide
CAS No.:1350618-51-7
Molecular Formula:C₁₆H₁₈N₄O₄
Molecular Weight:330.343
Hs Code.:

Synonyms:4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

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Chemical Property of 4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

Chemical Property:

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Technology Process of 4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

There total 6 articles about 4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1350618-50-6
tert-butyl 1-(4-(hydroxycarbamoyl)benzylamino)-3-(5-hydroxypyridin-2-yl)-1-oxopropan-2-ylcarbamate

: 1350618-51-7
4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1350618-51-7
4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

2.2: pH 2

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With water; hydrogen; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1350618-56-2
methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

: 1350618-51-7
4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

1.2: pH 2

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With water; hydrogen; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;