2-amino>acetaldehyde diethyl acetal

Base Information

• Chemical Name: 2-amino>acetaldehyde diethyl acetal
• CAS No.: 147807-85-0
• Molecular Formula: C₃₀H₃₉NO₅
• Molecular Weight: 493.643
• Mol file: 147807-85-0.mol

Synonyms:2-amino>acetaldehyde diethyl acetal

Chemical Property of 2-amino>acetaldehyde diethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino>acetaldehyde diethyl acetal

There total 9 articles about 2-amino>acetaldehyde diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2-diethoxy-ethanamine (645-36-3) + Benzyloxymethyl 2-benzyloxy-3-methoxy-4-methylphenyl ketone (147807-84-9) → 2-amino>acetaldehyde diethyl acetal (147807-85-0)

Guidance literature:

With sodium cyanoborohydride; magnesium sulfate; acetic acid; In ethanol; Heating;

Reference yield:

1,2-dimethoxy-3-methylbenzene (4463-33-6) → 2-amino>acetaldehyde diethyl acetal (147807-85-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 52 percent / TMEDA, BuLi / hexane / 1.) 0 deg C, 30 min; r.t., overnight, 2.) 0 deg C, 1 h

2: 77 percent / NaH, PrSH / dimethylformamide / 1.5 h / 90 °C

3: 93 percent / K₂CO₃ / ethanol / Heating

4: 100 percent / 50percent aq. NaOH, Bu₄NI / CH₂Cl₂ / 6 h / Heating

5: 66 percent / NaOCH₂Ph / 100 °C

6: 1.) DMSO, TFAA, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) -60 deg C, 15 min; r.t., 15 min

7: 89 percent / NaCNBH₃, MgSO₄, AcOH / methanol / Heating

With sodium hydroxide; n-butyllithium; 1-thiopropane; N,N,N,N,-tetramethylethylenediamine; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium cyanoborohydride; magnesium sulfate; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; sodium phenyl-methanolate; trifluoroacetic anhydride; In methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/P19960002497

Reference yield:

2?hydroxy?3?methoxy?4?methylbenzaldehyde (147807-80-5) → 2-amino>acetaldehyde diethyl acetal (147807-85-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / K₂CO₃ / ethanol / Heating

2: 100 percent / 50percent aq. NaOH, Bu₄NI / CH₂Cl₂ / 6 h / Heating

3: 66 percent / NaOCH₂Ph / 100 °C

4: 1.) DMSO, TFAA, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) -60 deg C, 15 min; r.t., 15 min

5: 89 percent / NaCNBH₃, MgSO₄, AcOH / methanol / Heating

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; sodium cyanoborohydride; magnesium sulfate; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; sodium phenyl-methanolate; trifluoroacetic anhydride; In methanol; ethanol; dichloromethane;

DOI:10.1039/P19960002497

upstream raw materials:

2,2-diethoxy-ethanamine

Benzyloxymethyl 2-benzyloxy-3-methoxy-4-methylphenyl ketone

1,2-dimethoxy-3-methylbenzene

2?hydroxy?3?methoxy?4?methylbenzaldehyde

Downstream raw materials:

8-Benzyloxy-1-benzyloxymethyl-7-methoxy-6-methyl-2-(p-tolylsulfonyl)-1,2-dihydroisoquinoline

1-Hydroxymethyl-7-methoxy-6-methyl-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-8-ol

6-[1-(2,2-Diethoxy-ethylamino)-2-hydroxy-ethyl]-2-methoxy-3-methyl-phenol

N-(2,2-Diethoxyethyl)-N-<1-(2-benzyloxy-3-methoxy-4-methylphenyl)-2-benzyloxyethyl>toluene-p-sulfonamide