3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

Base Information

Chemical Name:3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide
CAS No.:1346570-36-2
Molecular Formula:C₂₃H₁₉ClN₄O₂
Molecular Weight:418.882
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

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Chemical Property of 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

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Technology Process of 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

There total 8 articles about 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346569-76-3
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid

: 1346570-36-2
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

Guidance literature:: 3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With hydrazine hydrate; In tetrahydrofuran; at 0 - 10 ℃; for 1h; Inert atmosphere;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1346570-36-2
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 3 h / Reflux

1.2: 0.5 h / Reflux

2.1: sulfuric acid / 16 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

4.1: sodium hydroxide; water / ethanol / 16 h / 22 - 26 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1 h / 0 - 10 °C / Inert atmosphere

With sulfuric acid; water; chloroformic acid ethyl ester; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1.1: Perkin Reaction;

Reference yield:

: 57892-76-9
2-chloromethylimidazo[1,2-a]pyridine

: 1346570-36-2
3-(4-chlorophenyl)-2-[4-(imidazo[1,2-a]pyridin-2-ylmethoxy)phenyl]prop-2-enehydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2.1: sodium hydroxide; water / ethanol / 16 h / 22 - 26 °C

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 - 10 °C / Inert atmosphere

With water; chloroformic acid ethyl ester; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;