(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

Base Information

Chemical Name:(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride
CAS No.:1541199-37-4
Molecular Formula:C₁₅H₁₉ClF₃NO₂*ClH
Molecular Weight:374.231
Hs Code.:

Synonyms:(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

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Chemical Property of (S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

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Technology Process of (S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

There total 8 articles about (S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-17-5
ethanol

: 1541199-38-5
(S)-3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoic acid

: 1541199-37-4
(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: With hydrogenchloride; for 4h; Reflux;

Reference yield:

: 1541198-37-1
C₁₀H₉BrClF₃O₃S

: 1541199-37-4
(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane; toluene / 8 h / -78 - 25 °C / Inert atmosphere

2.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: ammonium acetate / ethanol / 7 h / 80 °C

4.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

4.2: 0.25 h / 20 °C

5.1: hydrogenchloride / 4 h / Reflux

With hydrogenchloride; potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; sodium hydroxide; In ethanol; hexane; dichloromethane; di-isopropyl ether; water; toluene;

Reference yield:

: 1541198-35-9
rac-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate

: 1541199-37-4
(S)-ethyl 3-amino-3-(3-chloro-5-(1,1,1-trifluoro-2-methylpropan-2-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 168 h / 20 °C / pH 8.32 / Enzymatic reaction

1.2: 0.25 h / 20 °C

2.1: hydrogenchloride / 4 h / Reflux

With hydrogenchloride; potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide; In water;