4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide
CAS No.:1355654-00-0
Molecular Formula:C₂₂H₂₂ClN₃O₆S
Molecular Weight:491.952
Hs Code.:

Synonyms:4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

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Chemical Property of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

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Technology Process of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

There total 7 articles about 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355656-89-1
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

: 124-63-0
methanesulfonyl chloride

: 1355654-00-0
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

Guidance literature:: 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide; With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.5h;

methanesulfonyl chloride; In tetrahydrofuran; for 1h;

Reference yield:

: 1344997-94-9
3-chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1355654-00-0
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: peracetic acid; acetic acid / water / 4 h / 0 - 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 4 h / 50 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

4.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 1 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h

5.2: 1 h

With peracetic acid; dihydrogen peroxide; sodium carbonate; potassium carbonate; acetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 1355066-41-9
5-chloro-6-(1-propan-2-yloxy)-3-pyridinol

: 1355654-00-0
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 4 h / 50 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

3.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 1 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h

4.2: 1 h

With dihydrogen peroxide; sodium carbonate; potassium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide;