4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

Base Information

Chemical Name:4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide
CAS No.:1355656-89-1
Molecular Formula:C₂₁H₂₀ClN₃O₄
Molecular Weight:413.861
Hs Code.:

Synonyms:4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

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Chemical Property of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

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Technology Process of 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

There total 6 articles about 4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1355656-87-9
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzonitrile

: 1355656-89-1
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

Guidance literature:: With dihydrogen peroxide; potassium carbonate; In water; dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 2402-77-9
2,3-dichloro-pyridine

: 1355656-89-1
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 1.83 h / 5 - 20 °C

1.2: 18 h / Reflux

2.1: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / n-heptane / 18 h / Inert atmosphere

3.1: peracetic acid; acetic acid / water / 4 h / 0 - 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 4 h / 50 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

6.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 1 h / 20 °C

With peracetic acid; dihydrogen peroxide; sodium hydride; sodium carbonate; potassium carbonate; acetic acid; 4,4'-di-tert-butyl-2,2'-bipyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; 1,4-dioxane; n-heptane; water; dimethyl sulfoxide;

Reference yield:

: 1344997-94-9
3-chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1355656-89-1
4-[(5-chloro-6-isopropoxypyridin-3-yl)oxy]-3-(2-methoxypyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: peracetic acid; acetic acid / water / 4 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 4 h / 50 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

4: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 1 h / 20 °C

With peracetic acid; dihydrogen peroxide; sodium carbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; dimethyl sulfoxide;