1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate
CAS No.:1416161-82-4
Molecular Formula:C₂₇H₃₁FN₂O₇
Molecular Weight:514.551
Hs Code.:

Synonyms:1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

There total 8 articles about 1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227685-41-7
(2S,4R)-1-benzyl 4-methyl 4-(3-fluorophenylamino)-2-methylpiperidine-1,4-dicarboxylate

: 36239-09-5
ethyl chlorocarbonylacetate

: 1416161-82-4
1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

Guidance literature:: (2S,4R)-1-benzyl 4-methyl 4-(3-fluorophenylamino)-2-methylpiperidine-1,4-dicarboxylate; ethyl chlorocarbonylacetate; at -5 - 5 ℃;

With hydrogenchloride; In water; at -5 ℃;

Reference yield:

: 190906-91-3
3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester

: 1416161-82-4
1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / zinc / 3 h / 60 °C

2.1: Chiralpak AD / methanol

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -70 - -20 °C

3.2: 12 h / -5 - 5 °C

4.1: tetrabutyl ammonium fluoride; acetic acid / 2-methyltetrahydrofuran / 0.5 h / 20 °C

5.1: 0 °C

5.2: 12 h / -5 - 20 °C

6.1: -5 - 5 °C

6.2: -5 °C

With tetrabutyl ammonium fluoride; acetic acid; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1416161-82-4
1-benzyl 4-methyl (2S,4R)-4-[(3-ethoxy-3-oxopropanoyl)(3-fluorophenyl)amino]-2-methylpiperidine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -50 - -10 °C

1.2: 3 h / -78 - 20 °C

2.1: acetic acid / zinc / 3 h / 60 °C

3.1: Chiralpak AD / methanol

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -70 - -20 °C

4.2: 12 h / -5 - 5 °C

5.1: tetrabutyl ammonium fluoride; acetic acid / 2-methyltetrahydrofuran / 0.5 h / 20 °C

6.1: 0 °C

6.2: 12 h / -5 - 20 °C

7.1: -5 - 5 °C

7.2: -5 °C

With tetrabutyl ammonium fluoride; acetic acid; triethylamine; lithium hexamethyldisilazane; zinc; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol;