2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate

Base Information

• Chemical Name: 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate
• CAS No.: 1039136-54-3
• Molecular Formula: C₁₅H₂₀F₃NO₃Si
• Molecular Weight: 347.409
• Mol file: 1039136-54-3.mol

Synonyms:2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate

Chemical Property of 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate

There total 2 articles about 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) + carbon monoxide (201230-82-2) + N-(p-Anisyl)-2,2,2-trifluoroacetimidoyl iodide (134481-27-9) → 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate (1039136-54-3)

Guidance literature:

With potassium carbonate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.jfluchem.2007.05.006

Reference yield:

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride (75999-66-5) → 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate (1039136-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / acetone

2: K₂CO₃ / Pd₂(dba)3 / toluene; dimethylformamide

With potassium carbonate; sodium iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1016/j.jfluchem.2007.05.006

Reference yield: 95.0%

2-iodo-propane (75-30-9) + 2-(trimethylsilyl)ethyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate (1039136-54-3) → C13H14F3NO3 (1039136-67-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jo800567a

upstream raw materials:

2-(Trimethylsilyl)ethanol

carbon monoxide

N-(p-Anisyl)-2,2,2-trifluoroacetimidoyl iodide

(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

Downstream raw materials:

2-(trimethylsilyl)ethyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

C₁₃H₁₄F₃NO₃

4-chlorobutyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate

but-3-enyl (E)-3,3,3-trifluoro-2-(4-methoxyphenylimino)propanoate