[5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester
• CAS No.: 111113-14-5
• Molecular Formula: C₂₃H₂₀FN₅O₂
• Molecular Weight: 417.443

Synonyms:[5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

Chemical Property of [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

Chemical Property:

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Technology Process of [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

There total 2 articles about [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester (103373-53-1) → [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester (111113-14-5)

Guidance literature:

With hydrazine; In methanol; at 23 ℃; for 1.5h;

DOI:10.1021/jm00396a028

Reference yield:

(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (103373-52-0) → [5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester (111113-14-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Lawesson's reagent / toluene / 1.5 h / Heating

2: NH₂NH₂ / methanol / 1.5 h / 23 °C

With Lawessons reagent; hydrazine; In methanol; toluene;

DOI:10.1021/jm00396a028

Reference yield: 60.0%

[5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester (111113-14-5) + trimethyl orthoformate (149-73-5) → 6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine (111113-16-7)

Guidance literature:

With sulfuric acid; In ethanol; at 23 ℃; for 10h;

DOI:10.1021/jm00396a028

upstream raw materials:

<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

Downstream raw materials:

6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

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