6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Base Information

Chemical Name:6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine
CAS No.:111113-16-7
Molecular Formula:C₂₄H₁₈FN₅O₂
Molecular Weight:427.438
Hs Code.:

Synonyms:6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

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Chemical Property of 6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

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Technology Process of 6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

There total 4 articles about 6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 111113-14-5
[5-(2-Fluoro-phenyl)-2-hydrazono-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester

: 149-73-5
trimethyl orthoformate

: 111113-16-7
6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Guidance literature:: With sulfuric acid; In ethanol; at 23 ℃; for 10h;
DOI:10.1021/jm00396a028

Reference yield:

: 103373-52-0
(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

: 111113-16-7
6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Lawesson's reagent / toluene / 1.5 h / Heating

2: NH₂NH₂ / methanol / 1.5 h / 23 °C

3: 60 percent / H₂SO₄ / ethanol / 10 h / 23 °C

With Lawessons reagent; sulfuric acid; hydrazine; In methanol; ethanol; toluene;
DOI:10.1021/jm00396a028

Reference yield:

: 103373-53-1
<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

: 111113-16-7
6-(2-Fluorophenyl)-4-benzyloxycarbonylamino-4H-s-triazolo[4,3-a]-1,4-benzodiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: NH₂NH₂ / methanol / 1.5 h / 23 °C

2: 60 percent / H₂SO₄ / ethanol / 10 h / 23 °C

With sulfuric acid; hydrazine; In methanol; ethanol;
DOI:10.1021/jm00396a028