3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester

Base Information

Chemical Name:3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester
CAS No.:594844-71-0
Molecular Formula:C12H14N2O5
Molecular Weight:266.254
Hs Code.:
Mol file:594844-71-0.mol

Synonyms:3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester;methyl 2-(3-(dimethylcarbamoyl)-4-nitrophenyl)acetate

Suppliers and Price of 3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester

Chemical Property:

PSA：92.43000
LogP:1.53530

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester

There total 6 articles about 3-[(diMethylaMino)carbonyl]-4-nitro-Benzeneacetic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 67-56-1
methanol

: 1350468-85-7
[3-(dimethylcarbamoyl)-4-nitrophenyl]acetic acid

: 594844-71-0
(3-dimethylcarbamoyl-4-nitrophenyl)acetic acid methyl ester

Guidance literature:: With acetyl chloride; at 0 - 20 ℃; for 3h;

Reference yield:

: 594844-70-9
2-(3-dimethylcarbamoyl-4-nitrophenyl)malonic acid tert-butyl ester methyl ester

: 594844-71-0
(3-dimethylcarbamoyl-4-nitrophenyl)acetic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 594844-71-0
(3-dimethylcarbamoyl-4-nitrophenyl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1 h / Reflux

2.1: triethylamine / tetrahydrofuran / 20 °C / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 3 h / 120 °C

4.1: hydrogenchloride; water / 3 h / Reflux

5.1: acetyl chloride / 3 h / 0 - 20 °C

With hydrogenchloride; water; sodium hydride; triethylamine; acetyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;