(R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

Base Information

Chemical Name:(R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane
CAS No.:1337973-25-7
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:(R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

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Chemical Property of (R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

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Technology Process of (R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

There total 9 articles about (R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1337973-24-6
(S)-3-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)butan-2-one

: 1779-49-3
Methyltriphenylphosphonium bromide

: 1337973-25-7
(R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.25h; Inert atmosphere;

(S)-3-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)butan-2-one; In tetrahydrofuran; hexane; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1227484-15-2
2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)acetic acid

: 1337973-25-7
(R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 1.25 h / -78 - 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

2.2: 2.25 h / -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.2 h / -78 °C / Inert atmosphere

3.2: 6 h / -78 - 20 °C / Inert atmosphere

4.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

4.2: pH 2 - 3 / Inert atmosphere

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C / Inert atmosphere

6.1: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Inert atmosphere

6.2: Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 20 °C / Inert atmosphere

7.2: 4 h / 20 °C / Inert atmosphere

With n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; 7.2: Wittig reaction;
DOI:10.1007/s12272-011-0805-9

Reference yield:

: 1337973-21-3
(S)-4-benzyl-3-((S)-2-(5-((tert-butyldimethylsilyloxy)methyl)-4-methoxy-2-(methoxymethoxy)phenyl)propanoyl)oxazolidin-2-one

: 1337973-25-7
(R)-tert-butyl(2-methoxy-4-(methoxymethoxy)-5-(3-methylbut-3-en-2-yl)benzyloxy)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

1.2: pH 2 - 3 / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 10 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 3 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / 20 °C / Inert atmosphere

4.2: 4 h / 20 °C / Inert atmosphere

With n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; 4.2: Wittig reaction;
DOI:10.1007/s12272-011-0805-9