4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde

Base Information

• Chemical Name: 4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde
• CAS No.: 1338227-36-3
• Molecular Formula: C₁₄H₂₀O₆
• Molecular Weight: 284.309
• Mol file: 1338227-36-3.mol

Synonyms:4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde

Chemical Property of 4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde

There total 1 articles about 4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) + vanillin (121-33-5,8014-42-4) → 4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde (1338227-36-3)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 5h;

DOI:10.1016/j.bmcl.2011.08.003

Reference yield: 95.7%

4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde (1338227-36-3) + methanesulfonyl chloride (124-63-0) → 4-(2-(2-(2-methanesulfonyloxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde (1338227-38-5)

Guidance literature:

4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

methanesulfonyl chloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2011.08.003

Reference yield:

4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde (1338227-36-3) → 4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde (1338227-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: cesium fluoride / acetonitrile / 17 h / 100 °C

With triethylamine; cesium fluoride; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2011.08.003

upstream raw materials:

2-[2-(chloroethoxy)ethoxy]ethanol

vanillin

Downstream raw materials:

4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde

(1E,4Z,6E)-7-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-3-methoxyphenyl)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one

4-(2-(2-(2-methanesulfonyloxyethoxy)ethoxy)ethoxy)-3-methoxybenzaldehyde