2,2-dimethyl-4-phenylbutyric acid methyl ester

Base Information

• Chemical Name: 2,2-dimethyl-4-phenylbutyric acid methyl ester
• CAS No.: 15116-28-6
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 15116-28-6.mol

Synonyms:2,2-dimethyl-4-phenylbutyric acid methyl ester

Chemical Property of 2,2-dimethyl-4-phenylbutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-4-phenylbutyric acid methyl ester

There total 7 articles about 2,2-dimethyl-4-phenylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + (3-iodo-3-methyl-n-butyl)benzene → 2,2-dimethyl-4-phenylbutyric acid methyl ester (15116-28-6)

Guidance literature:

With indium iodide; copper(I) triflate; potassium carbonate; In 1,4-dioxane; at 20 ℃; for 24h; under 760.051 Torr; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01573

Reference yield: 12.0%

2-methyl-4-phenylbutyric acid methyl ester (38795-58-3) + methyl iodide (74-88-4) → 2,2-dimethyl-4-phenylbutyric acid methyl ester (15116-28-6)

Guidance literature:

2-methyl-4-phenylbutyric acid methyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -10 ℃; Inert atmosphere;

methyl iodide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.783333h; Inert atmosphere;

DOI:10.1021/ja211679v

Reference yield:

2,2-dimethoxy-3,3-dimethyl-5-phenyl-2,3-dihydro-furan (14308-33-9) → 2,2-dimethyl-4-phenylbutyric acid methyl ester (15116-28-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In 1,4-dioxane;

upstream raw materials:

2,2-dimethoxy-3,3-dimethyl-5-phenyl-2,3-dihydro-furan

styrene

Methyl isobutyrate

2-methyl-4-phenylbutyric acid methyl ester

Downstream raw materials:

2,2-dimethyl-4-phenylbutyric acid

tert-butyl 2,2-dimethyl-4-phenylbutaneperoxoate

2,2-dimethyl-4-phenyl-N-(quinolin-8-yl)butanamide

3-methyl-3-phenethyl-1-(quinolin-8-yl)azetidin-2-one