5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine
CAS No.:799811-47-5
Molecular Formula:C₅₁H₅₂N₄O₉
Molecular Weight:864.995
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 799811-46-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

: 799811-47-5
5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Guidance literature:: With triethylamine tris-hydrofluoride; pyridine hydrochloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/b402414a

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 799811-47-5
5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / pyridine / 20 °C

2: 70 percent / triethylamine tris-hydrofluoride; pyridine hydrochloride / tetrahydrofuran / 20 °C

With triethylamine tris-hydrofluoride; pyridine hydrochloride; In tetrahydrofuran; pyridine;
DOI:10.1039/b402414a

Reference yield:

: 165306-22-9
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 799811-47-5
5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: tetrahydrofuran / 50 °C

3: 98 percent / pyridine / 20 °C

4: 70 percent / triethylamine tris-hydrofluoride; pyridine hydrochloride / tetrahydrofuran / 20 °C

With pyridine; triethylamine tris-hydrofluoride; pyridine hydrochloride; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1039/b402414a