3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Base Information

Chemical Name:3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine
CAS No.:799811-46-4
Molecular Formula:C₅₇H₆₆N₄O₉Si
Molecular Weight:979.258
Hs Code.:

Synonyms:3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

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Chemical Property of 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

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Technology Process of 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

There total 3 articles about 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 799811-45-3
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-4'-C-piperazino-methylthymidine

: 799811-46-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Guidance literature:: In pyridine; at 20 ℃;
DOI:10.1039/b402414a

Reference yield:

: 165306-22-9
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 799811-46-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: tetrahydrofuran / 50 °C

3: 98 percent / pyridine / 20 °C

With pyridine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1039/b402414a

Reference yield:

: trifluoro-methanesulfonic acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 799811-46-4
3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 50 °C

2: 98 percent / pyridine / 20 °C

In tetrahydrofuran; pyridine;
DOI:10.1039/b402414a