2-(4-Methoxyphenyl)-1-phenylpropan-2-ol

Base Information

Chemical Name:2-(4-Methoxyphenyl)-1-phenylpropan-2-ol
CAS No.:22926-97-2
Molecular Formula:C₁₆H₁₈O₂
Molecular Weight:242.318
Hs Code.:
DSSTox Substance ID:DTXSID601267348

Synonyms:2-(4-methoxyphenyl)-1-phenylpropan-2-ol;DTXSID601267348;alpha-(4-Methoxyphenyl)-alpha-methylbenzeneethanol;22926-97-2

Suppliers and Price of 2-(4-Methoxyphenyl)-1-phenylpropan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Methoxyphenyl)-1-phenylpropan-2-ol

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:242.130679813
Heavy Atom Count:18
Complexity:240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CC1=CC=CC=C1)(C2=CC=C(C=C2)OC)O

Technology Process of 2-(4-Methoxyphenyl)-1-phenylpropan-2-ol

There total 9 articles about 2-(4-Methoxyphenyl)-1-phenylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5281-18-5
benzaldehyde, hydrazone

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 22926-97-2
2-(4-methoxyphenyl)-1-phenylpropan-2-ol

Guidance literature:: With potassium phosphate; Fe(1,2-bis(dimethylphosphino)ethane)2Cl₂; cesium fluoride; In tetrahydrofuran; at 20 ℃; for 24h; Glovebox; Inert atmosphere;
DOI:10.1021/acs.orglett.8b01391

Reference yield:

: 100-44-7
benzyl chloride

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 22926-97-2
2-(4-methoxyphenyl)-1-phenylpropan-2-ol

Guidance literature:: benzyl chloride; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h; Inert atmosphere;

1-(4-methoxyphenyl)ethanone; In tetrahydrofuran; for 1.5h; Inert atmosphere;
DOI:10.1016/j.jphotochem.2016.07.001

Reference yield:

: 100-52-7
benzaldehyde

: 22926-97-2
2-(4-methoxyphenyl)-1-phenylpropan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / tetrahydrofuran / 0.5 h / 20 °C

2: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium phosphate; cesium fluoride; 1,2-bis(dimethylphosphanyl)ethane / tetrahydrofuran / 3 h / 45 °C / Inert atmosphere

With potassium phosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1,2-bis(dimethylphosphanyl)ethane; hydrazine hydrate; cesium fluoride; In tetrahydrofuran;
DOI:10.1038/nchem.2677