Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester
• CAS No.: 102213-03-6
• Molecular Formula: C₃₇H₄₇N₄O₇P
• Molecular Weight: 690.777
• Mol file: 102213-03-6.mol

Synonyms:Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester

Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester

There total 1 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis(N,N-diisopropylamino)methoxyphosphine (92611-10-4) + 5'-O-(4,4'-dimethoxytrityl)deoxycytidine (76512-82-8) → Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester (102213-03-6)

Guidance literature:

DOI:10.1021/ja00015a059

Reference yield: 95.0%

Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester (102213-03-6) → 5'-O-(p,p'-dimethoxytrityl)-2'-deoxycytidine 3-methyl H-phosphonate

Guidance literature:

With 1H-tetrazole; water; In acetonitrile; at 20 ℃;

DOI:10.1016/S0968-0896(99)00287-4

Reference yield:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester (102213-03-6) → 2'-deoxycytidylyl-(3',5')-thymidine phosphate (4829-64-5)

Guidance literature:

Multistep reaction;

DOI:10.1021/ja048125h

upstream raw materials:

bis(N,N-diisopropylamino)methoxyphosphine

5'-O-(4,4'-dimethoxytrityl)deoxycytidine

Downstream raw materials:

2'-deoxycytidylyl-(3',5')-thymidine phosphate