Cbz-Gly-L-Phe-L-Leu-OEt

Base Information

• Chemical Name: Cbz-Gly-L-Phe-L-Leu-OEt
• CAS No.: 3982-72-7
• Molecular Formula: C₂₇H₃₅N₃O₆
• Molecular Weight: 497.591
• Mol file: 3982-72-7.mol

Synonyms:Cbz-Gly-L-Phe-L-Leu-OEt

Chemical Property of Cbz-Gly-L-Phe-L-Leu-OEt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-Gly-L-Phe-L-Leu-OEt

There total 5 articles about Cbz-Gly-L-Phe-L-Leu-OEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Z-phenylalanylleucine ethyl ester (2953-42-6) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → Cbz-Gly-L-Phe-L-Leu-OEt (3982-72-7)

Guidance literature:

Z-phenylalanylleucine ethyl ester; With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In water; at 20 - 25 ℃; for 2h;

N-(Benzyloxycarbonyl)glycine; With 2,6-dimethylpyridine; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; In water; at 20 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c7gc01575e

Reference yield:

N-Cbz-L-Phe (1161-13-3) → Cbz-Gly-L-Phe-L-Leu-OEt (3982-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / water

1.2: 12 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / water / 2 h / 20 - 25 °C

2.2: 2 h / 20 - 25 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In water;

DOI:10.1039/c7gc01575e

Reference yield:

L-leucine ethyl ester hydrochloride (2743-40-0) → Cbz-Gly-L-Phe-L-Leu-OEt (3982-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; 2,6-dimethylpyridine / water / 20 - 25 °C

2.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / water / 2 h / 20 - 25 °C

2.2: 2 h / 20 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; hydrogenchloride; 1-[(1-(cyano-?2-?ethoxy-?2-?oxoethylidenaminooxy)?dimethylamino-?morpholino)]-uronium hexafluorophosphate; palladium 10% on activated carbon; hydrogen; In water;

DOI:10.1039/c7gc01575e

upstream raw materials:

Z-phenylalanylleucine ethyl ester

N-(Benzyloxycarbonyl)glycine

N-Cbz-L-Phe

L-leucine ethyl ester hydrochloride

Refernces