2953-42-6Relevant articles and documents
Tandem deprotection/coupling for peptide synthesis in water at room temperature
Cortes-Clerget, Margery,Berthon, Jean-Yves,Krolikiewicz-Renimel, Isabelle,Chaisemartin, Laurent,Lipshutz, Bruce H.
supporting information, p. 4263 - 4267 (2017/09/28)
A tandem deprotection/coupling sequence is reported for solution-phase peptide synthesis in water under micellar catalysis conditions using the designer surfactant TPGS-750-M. Cbz deprotection followed by peptide coupling in the presence of COMU and 2,6-lutidine afforded polypeptides containing up to 10 amino acid residues. A broad scope characterizes this new technology. No epimerization has been detected. The associated E Factors, as a measure of "greenness" and known to be extremely high for peptide couplings, have been reduced to less than 10 due to the step-economy and minimal amounts of organic solvent needed for product extraction.
Fully enzymatic peptide synthesis using C-terminal tert-butyl ester interconversion
Nuijens, Timo,Cusan, Claudia,Van Dooren, Theodorus J. G. M.,Moody, Harold M.,Merkx, Remco,Kruijtzer, John A. W.,Rijkers, Dirk T. S.,Liskamp, Rob M. J.,Quaedflieg, Peter J. L. M.
experimental part, p. 2399 - 2404 (2011/02/21)
Chemoenzymatic peptide synthesis is potentially the most cost-efficient technology for the synthesis of short and medium-sized peptides with some important advantages. For instance, stoichiometric amounts of expensive coupling reagents are not required an
Facile One-Pot Amidation of Carboxylic Acids by Amines Catalyzed by Triphenylstibine Oxide/Tetraphosphorus Decasulfide (Ph3SbO/P4S10)
Nomura, Ryoki,Nakano, Takahiro,Yamada, Yasuhiro,Matsuda, Haruo
, p. 4076 - 4078 (2007/10/02)
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