methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate

Base Information

• Chemical Name: methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate
• CAS No.: 89581-64-6
• Molecular Formula: C₆H₅ClN₂O₃
• Molecular Weight: 188.57
• Hs Code.: 2933998090
• Mol file: 89581-64-6.mol

Synonyms:methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate

Chemical Property of methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

methyl6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate

There total 4 articles about methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (50681-26-0) → methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate (89581-64-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 20h;

Reference yield:

methyl 3,6-dichloropyridazine-4-carboxylate (286946-24-5) → methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate (89581-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 20 h / 90 °C

2: hydrogenchloride / 1,4-dioxane / 20 h / 50 °C

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

3,6-dichloropyridazin-4-carboxylic acid (51149-08-7) → methyl 6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylate (89581-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 4 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 20 h / 50 °C

With hydrogenchloride; acetic acid; In 1,4-dioxane;

DOI:10.1021/acs.jmedchem.0c00346

upstream raw materials:

methanol

6-chloro-3-oxo-2,3-dihydropyridazine-4-carboxylic acid

methyl 3,6-dichloropyridazine-4-carboxylate

3,6-dichloropyridazin-4-carboxylic acid

Downstream raw materials:

C₆H₆N₂O₃

C₁₃H₉ClF₂N₂O₃

C₁₂H₇ClF₂N₂O₃

C₁₃H₁₀F₂N₂O₄