2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 940391-41-3
• Molecular Formula: C₁₃H₁₀FN₃S
• Molecular Weight: 259.307
• Mol file: 940391-41-3.mol

Synonyms:2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

There total 1 articles about 2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-amino-5-cyclopropyl-1,3,4-thiadiazole (57235-50-4) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole (940391-41-3)

Guidance literature:

2-amino-5-cyclopropyl-1,3,4-thiadiazole; 2-bromo-4'-fluoroacetophenone; In ethanol; for 16h; Reflux;

With sodium carbonate; In water;

DOI:10.1016/j.ejmech.2011.07.012

Reference yield: 68.0%

2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole (940391-41-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde

Guidance literature:

With trichlorophosphate; at 0 - 60 ℃; for 4.5h;

DOI:10.1016/j.ejmech.2014.09.002

Reference yield: 54.0%

2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole (940391-41-3) + potassium thioacyanate (333-20-0) → 2-cyclopropyl-6-(4-fluorophenyl)-5-thiocyanatoimidazo[2,1-b][1,3,4]thiadiazole (1335016-79-9)

Guidance literature:

With bromine; acetic acid; at 20 - 25 ℃; for 1.5h;

DOI:10.1016/j.ejmech.2011.07.012

upstream raw materials:

2-amino-5-cyclopropyl-1,3,4-thiadiazole

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

5-bromo-2-cyclopropyl-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

2-cyclopropyl-6-(4-fluorophenyl)-5-thiocyanatoimidazo[2,1-b][1,3,4]thiadiazole