Technology Process of [6-phenyl-piperidin-(2Z)-ylidene]-hydrazine
There total 5 articles about [6-phenyl-piperidin-(2Z)-ylidene]-hydrazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-phenylpiperidin-2-one;
With
methyl trifluoromethanesulfonate;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
With
hydrazine;
In
methanol; dichloromethane;
at 0 - 20 ℃;
for 3.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / ethyl acetate; water / 2 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -50 °C
2.2: 0.58 h / -50 - 20 °C
3.1: triethylamine; lithium chloride / acetonitrile / 18 h / 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr
5.1: methyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
5.2: 3.5 h / 0 - 20 °C / Inert atmosphere
With
oxalyl dichloride; hydrogen; sodium carbonate; dimethyl sulfoxide; triethylamine; methyl trifluoromethanesulfonate; lithium chloride;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; water; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / 2327.23 Torr
2.1: methyl trifluoromethanesulfonate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2.2: 3.5 h / 0 - 20 °C / Inert atmosphere
With
hydrogen; methyl trifluoromethanesulfonate;
palladium 10% on activated carbon;
In
ethanol; dichloromethane;
