(4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

Base Information

Chemical Name:(4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene
CAS No.:143143-21-9
Molecular Formula:C₂₂H₂₄F₃NO₃
Molecular Weight:407.433
Hs Code.:

Synonyms:(4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

Suppliers and Price of (4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

Chemical Property:

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Technology Process of (4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

There total 4 articles about (4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53643-20-2
(1R,2R)-norephedrine hydrochloride

: 143143-21-9
(4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / methanol / 18 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

3: 1.) TMSOTf / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, 48 h

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 205869-11-0
2,2,2-Trifluoro-N-((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-acetamide

: 143143-21-9
(4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: 1.) TMSOTf / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) CH₂Cl₂, 48 h

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 143143-10-6
(R,R)-2-trifluoroacetylamino-1-trimethylsilyloxy-1-phenylpropane

: 2,2,2-Trifluoro-1-[(2S,4R,5R)-2-(4-methoxy-phenyl)-4-methyl-5-phenyl-oxazolidin-3-yl]-ethanone

: 143143-21-9
(4S,1'R,2'R)-4-(p-methoxyphenyl)-4-(2'-trifluoroacetamido-1'-phenylpropoxy)but-1-ene

: 2,2,2-Trifluoro-N-((1R,2R)-2-{(4-methoxy-phenyl)-[(1R,2R)-1-phenyl-2-(2,2,2-trifluoro-acetylamino)-propoxy]-methoxy}-1-methyl-2-phenyl-ethyl)-acetamide

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; allyl-trimethyl-silane; Yield given. Multistep reaction. Yields of byproduct given; 1) CH₂Cl₂, -78 deg C, 1 h, 2) -78 deg C, 48 h;