diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Base Information

• Chemical Name: diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate
• CAS No.: 1179329-41-9
• Molecular Formula: C₃₀H₃₀F₅N₄O₆P
• Molecular Weight: 668.557
• Mol file: 1179329-41-9.mol

Synonyms:diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Chemical Property of diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate

There total 6 articles about diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + 1-(2-amino-4-fluorobenzyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-5,5-dimethylimidazolidine-2,4-dione (1006899-36-0) + diethyl (4-aminophenyl)phosphonate (42822-57-1) → diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate (1179329-41-9)

Guidance literature:

phosgene; 1-(2-amino-4-fluorobenzyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-5,5-dimethylimidazolidine-2,4-dione; In toluene; acetonitrile; at 75 - 80 ℃; for 2h; Inert atmosphere;

diethyl (4-aminophenyl)phosphonate; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

(4-fluoro-3-nitrophenyl)methanol (20274-69-5) → diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate (1179329-41-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: phosphorus tribromide / dichloromethane / 20 °C

2.1: caesium carbonate / acetonitrile

3.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

4.1: toluene; acetonitrile / 2 h / 75 - 80 °C / Inert atmosphere

4.2: 20 °C

With H₃B*NMe₃; phosphorus tribromide; caesium carbonate; 20 % Pd(OH)2/C; In methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

1-fluoro-4-isocyanato-2-(trifluoromethyl)benzene → diethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate (1179329-41-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 70 °C

1.2: 2 h / 70 °C

2.1: caesium carbonate / acetonitrile

3.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

4.1: toluene; acetonitrile / 2 h / 75 - 80 °C / Inert atmosphere

4.2: 20 °C

With H₃B*NMe₃; caesium carbonate; triethylamine; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; toluene; acetonitrile;

upstream raw materials:

(4-fluoro-3-nitrophenyl)methanol

phosgene

1-(2-amino-4-fluorobenzyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-5,5-dimethylimidazolidine-2,4-dione

diethyl (4-aminophenyl)phosphonate

Downstream raw materials:

[4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonic acid

monoethyl [4-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)phenyl]phosphonate