6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

Base Information

• Chemical Name: 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone
• CAS No.: 80170-81-6
• Molecular Formula: C₂₀H₂₁ClN₂O₂
• Molecular Weight: 356.852

Synonyms:6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

Chemical Property of 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

Chemical Property:

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Technology Process of 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone

There total 8 articles about 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

6-chloro-3-cyclohexyl-3,4-dihydro-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone (80170-56-5) → 1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea (25514-22-1) + 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone (80170-81-6)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; for 1h; Ambient temperature;

DOI:10.1248/cpb.29.2135

Reference yield: 28.0%

1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea (25514-22-1) → 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone (80170-81-6)

Guidance literature:

With trichlorophosphate; In xylene; for 5h; Heating;

DOI:10.1248/cpb.29.2135

Reference yield: 8.0%

5-chloro-2-trichloroacetylaminobenzophenone (26381-66-8) + cyclohexylamine (108-91-8,157973-60-9) → 5-chloro-2-dichloroacetamidobenzophenone (17387-32-5) + 1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea (25514-22-1) + 5-chloro-2-aminobenzophenone (719-59-5) + 6-chloro-3-cyclohexyl-3,4-dihydro-4-hydroxy-4-phenyl-2(1H)-quinazolinone (80170-81-6)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide; at 100 ℃; for 7h; Further byproducts given;

DOI:10.1248/cpb.29.2135

upstream raw materials:

1-(2-benzoyl-4-chlorophenyl)-3-cyclohexylurea

5-chloro-2-trichloroacetylaminobenzophenone

cyclohexylamine

6-chloro-3-cyclohexyl-3,4-dihydro-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone

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