(Z)-N,N-diethyl-3-phenylbut-2-enamide

Base Information

Chemical Name:(Z)-N,N-diethyl-3-phenylbut-2-enamide
CAS No.:6292-08-6
Molecular Formula:C₁₄H₁₉NO
Molecular Weight:217.311
Hs Code.:
DSSTox Substance ID:DTXSID10474556
NSC Number:8352
Wikidata:Q82304639

Synonyms:NSC8352;6292-08-6;DTXSID10474556;NSC-8352

Suppliers and Price of (Z)-N,N-diethyl-3-phenylbut-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (Z)-N,N-diethyl-3-phenylbut-2-enamide

Chemical Property:

Vapor Pressure:1.88E-05mmHg at 25°C
Boiling Point:362.8°Cat760mmHg
Flash Point:163.1°C
Density:0.984g/cm³
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:217.146664230
Heavy Atom Count:16
Complexity:248

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)C=C(C)C1=CC=CC=C1
Isomeric SMILES:CCN(CC)C(=O)/C=C(/C)\C1=CC=CC=C1

Technology Process of (Z)-N,N-diethyl-3-phenylbut-2-enamide

There total 8 articles about (Z)-N,N-diethyl-3-phenylbut-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 704-80-3
(E)-3-phenyl-2-butenoic acid

: 109-89-7
diethylamine

: 106914-36-7,6292-08-6
(E)-N,N-diethyl-3-phenylbut-2-enamide

Guidance literature:: (E)-3-phenyl-2-butenoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3.5h;

diethylamine; With triethylamine; In dichloromethane;
DOI:10.1021/acs.orglett.9b00729

Reference yield: 68.0%

: 3699-76-1
diethyl <(diethylcarbamoyl)methyl>phosphonate

: 98-86-2
acetophenone

: 106914-36-7,6292-08-6
(E)-N,N-diethyl-3-phenylbut-2-enamide

Guidance literature:: diethyl <(diethylcarbamoyl)methyl>phosphonate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

acetophenone; In tetrahydrofuran; mineral oil; at 40 ℃; for 24h; Inert atmosphere; Schlenk technique;
DOI:10.1039/c8cc09853k

Reference yield:

: 945-93-7,13979-22-1,1504-72-9
ethyl (E)-3-phenylbut-2-enoate

: 106914-36-7,6292-08-6
(E)-N,N-diethyl-3-phenylbut-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; ethanol

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 20 °C

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1021/acs.orglett.9b00729