Technology Process of methyl 3-(1-(4-chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate
There total 5 articles about methyl 3-(1-(4-chlorophenyl)cyclopropyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine;
at 50 ℃;
under 1292.9 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1.17 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: trichlorophosphate / toluene / 18 h / Reflux
3.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / 50 °C / 1292.9 Torr / Inert atmosphere
With
4-methyl-morpholine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; trichlorophosphate; isobutyl chloroformate;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1.17 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: trichlorophosphate / toluene / 18 h / Reflux
3.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / 50 °C / 1292.9 Torr / Inert atmosphere
With
4-methyl-morpholine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine; trichlorophosphate; isobutyl chloroformate;
In
tetrahydrofuran; toluene;
