ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

Base Information

Chemical Name:ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate
CAS No.:454437-48-0
Molecular Formula:C₃₇H₄₆N₄O₉S
Molecular Weight:722.86
Hs Code.:

Synonyms:ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

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Chemical Property of ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

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Technology Process of ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

There total 8 articles about ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 105-36-2
ethyl bromoacetate

: 179756-31-1
tert-butyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)carbamate

: 454437-48-0
ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 454437-48-0
ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 79 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 89 percent / pyridine / 15 h / 3 °C

5: 74 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 454437-48-0
ethyl N-(N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-N-[(7-cyano-2-naphthyl)methyl]sulfamoyl)-N-tert-butoxycarbonyl glycinate

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 79 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 89 percent / pyridine / 15 h / 3 °C

5: 74 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7